Cores for technetium radiopharmaceuticals

Details Cores for technetium radiopharmaceuticals Cores for technetium radiopharmaceuticals

A - Human Necessities

61

K

167/48

A61K 51/04 (2006.01) C07B 59/00 (2006.01)

Patent

CA 2039732

2039732 9103262 PCTABS00003 Novel complexes of technetium (99Tc or 99mTc) which contain the moiety Tc=NR, Tc-N=NY or Tc(-N=NY)2, and a ligand which confers biological target-seeking properties on the complex, wherein R represents an aryl group, a substituted or unsubstituted alkyl group, or the grouping =NR1R2; Y represents an aryl group or a substituted or unsubstituted alkyl group; and R1 and R2 are hydrogen, aryl groups or substituted or unsubstituted aliphatic or cyclic alkyl groups, and may be both the same or different, provided that both are not hydrogen. The complexes are suitable for use in radiopharmaceuticals for a variety of clinical applications. Methods for the preparation of these technetium complexes are also described.

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