Correction of genetic defects using chemical chaperones

Details Correction of genetic defects using chemical chaperones Correction of genetic defects using chemical chaperones

A - Human Necessities

61

K

A61K 45/00 (2006.01) A61K 31/047 (2006.01) A61K 31/10 (2006.01) A61K 31/131 (2006.01) A61K 31/185 (2006.01) A61K 31/197 (2006.01) A61K 31/198 (2006.01) A61K 31/205 (2006.01) A61K 31/401 (2006.01) A61K 31/77 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2250780

A method for stabilizing intracellular proteins known to cause disease, said method comprising contacting a cell with stabilizing agents such as DMSO, sugars, amino acids and TMAO, wherein the proteins are stabilized and the disease state lessened.

On décrit un procédé de stabilisation de protéines intracellulaires connues pour provoquer des maladies, ce procédé consistant à mettre en contact une cellule avec des agents stabilisants tels que du diméthylsulfoxyde, des sucres, des acides aminés et du triméthylamine N-oxyde, ce qui permet de stabilitiser les protéines et d'atténuer l'état maladif.

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