Corroles for neuroprotection and neurorescue

Details Corroles for neuroprotection and neurorescue Corroles for neuroprotection and neurorescue

C - Chemistry, Metallurgy

07

D

C07D 487/22 (2006.01) A61K 31/409 (2006.01) A61P 3/10 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2751058

Transition metal complexes of amphiphilic corroles, optical isomers and pharmaceutically acceptable salts thereof are useful for neuroprotection and neurorescue, particularly for treatment of diabetes and neurodegenerative diseases. The am-phiphilic corrole is preferably a 5,10,15-tris-aryl- or 5,10,15-tris-CF3-corrole, and said transition metal complex more preferably has the formula I defined in the specification. Also provided are propargyl- containing corroles carrying one or more radicals sub-stituted by a propargylamino group or one or more nitrogen-containing heteroaryl radicals substituted by propargyl at the ring N atom.

L'invention concerne des complexes de métaux de transition de corroles amphiphiles, leurs isomères optiques et leurs sels pharmaceutiquement acceptables, utiles pour la neuroprotection et la sauvegarde neurologique, en particulier pour le traitement du diabète et des maladies neurodégénératives. Le corrole amphiphile est de préférence un 5,10,15-tris-aryl- ou 5,10,15- tris-CF3-corrole, et ledit complexe de métaux de transition présente de manière davantage préférée, la formule I définie dans la description. L'invention concerne également des corroles contenant un groupe propargyle portant un ou plusieurs radicaux substitués par un groupe propargylamino ou un ou plusieurs radicaux hétéroaryle contenant de l'azote, substitués par un groupe propargyle au niveau de l'atome d'azote cyclique.

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