Corticoid-17-alkylcarbonates substituted in the 17-position,...

Details Corticoid-17-alkylcarbonates substituted in the 17-position,... Corticoid-17-alkylcarbonates substituted in the 17-position,...

C - Chemistry, Metallurgy

07

J

C07J 7/00 (2006.01) A61K 31/57 (2006.01) C07J 5/00 (2006.01) C07J 21/00 (2006.01) C07J 31/00 (2006.01)

Patent

CA 2048841

- 1 - HOE 90/F 241 Abstract of the Disclosure Corticoid-17-alkylcarbonates substituted in the 17-position, process for their preparation and pharma- ceuticals containing them. Corticoid-17-alkylcarbonates of the formula I Image I, where A is CHOH in any desired steric arrangement, C=O or CH2; Y is H, F, or Cl; Z is H, F or CH3; R(1) is Hal, O-acyl, carbonylalkyl, alkylsulfonate or arylsulfonate; R(2) is branched alkyl or (CH2)2-4-OCH3 and R(3) is H or methyl have excellent local and topical antiinflammatory action. They are distinguished by a particularly good ratio of local to systemic antiinflammatory activity and in some cases also show stronger local antiinflammatory activities than their isomeric corticoid-17-alkyl- carbonates having a linear alkyl group in the 17-alkylcarbonate moiety.

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