Corticoid derivatives and pharmaceutical and cosmetic...

Details Corticoid derivatives and pharmaceutical and cosmetic... Corticoid derivatives and pharmaceutical and cosmetic...

C - Chemistry, Metallurgy

07

J

C07J 17/00 (2006.01) A61K 8/63 (2006.01) A61K 31/665 (2006.01) C07J 5/00 (2006.01) C07J 7/00 (2006.01) C07J 71/00 (2006.01) A61K 7/00 (1995.01) A61K 31/705 (1995.01)

Patent

CA 2139549

A corticoid derivative of the general formula Image (I) wherein R represents hydrogen, hydroxy, methyl or methylene; inclusive of the acylation product thereof where the 17-position of the steroid skeleton is hydroxy and the ketone form thereof where R is hydroxy, or a physiologically acceptable salt thereof. Since the corticosteroid derivative of this invention is readily soluble in water and has anti- allergic, antiinflammatory and antioxidant activities, it can be used with advantage in the prevention and therapy of various allergic diseases, inflammatory diseases, cataract and various ischemic organ diseases. Furthermore, the present compound is of value as an ultraviolet absorber, a skin care ingredient, or a stabilizer for other cosmetic ingredients in the field of cosmetics.

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