Corticold hormones

Details Corticold hormones Corticold hormones

C - Chemistry, Metallurgy

07

J

260/64

C07J 5/00 (2006.01)

Patent

CA 1040191

ABSTRACT OF THE DISCLOSURE A new corticoid of the general formula Image (I) which has pronounced anti-inflammatory activity, and wherein X represents a .beta.-hydroxymethylene or carbonyl group, and R represents a hydrogen atom or a physiologically tolerable acyl group is produced by splitting hydrogen bromide from a compound of the general formula (II) Image wherein X and R have the above meanings. For example, 6.alpha.-fluoro-9.alpha.- bromo-11.beta.-hydroxy-21-hexanoyloxy-16.alpha.-methyl-.DELTA.1,4-pregnadiene- 3,20-dione is heated in the presence of collidine to produce 6.alpha.-fluoro-11.beta.-hydroxy-21-hexanoyloxy-16.alpha.-methyl-.DELTA.1,4,8-pregna- triene-3,20-dione.

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