C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/16 (2006.01) A61K 31/195 (2006.01) A61K 31/70 (2006.01) A61K 38/03 (2006.01) A61K 38/22 (2006.01) A61K 39/395 (2006.01) C07K 4/12 (2006.01) C07K 14/575 (2006.01) C07K 16/26 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2199734
The invention features a substantially pure preparation of a peptide having corticotropin release inhibiting factor (CRIF) activity comprising at least three contiguous amino acids contained within the amino acid sequence positioned between the fourth and fifth thyrotropin releasing hormone (TRH) sequence on a prepro-TRH protein. The CRIF peptide further comprises the fourth uncleaved TRH portion of prepro-TRH positioned at the amino terminus of CRIF. Compositions, methods of diagnosis and methods of treating CRIF related diseases are also included in the invention.
L'invention concerne une préparation pratiquement pure d'un peptide, doté d'une activité de facteur inhibiteur de libération de la corticotropine (CRIF), qui comprend au moins trois acides aminés contigus placés dans la séquence d'acides aminés située entre la quatrième et la cinquième séquences de l'hormone de libération de la thyrotropine (TRH) d'une protéine pré-proTRH. Ce peptide CRIF comprend en outre la quatrième partie TRH non coupée de pré-proTRH placée au terminal amino du CRIF. Des compositions et procédés de diagnostic et de traitement de maladies liées au CRIF sont également inclus dans l'invention.
Aird Fraser
Redei Eva
Gowling Lafleur Henderson Llp
The Trustees Of The University Of Pennsylvania
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