Corticotropin releasing factor against antagonist

Details Corticotropin releasing factor against antagonist Corticotropin releasing factor against antagonist

C - Chemistry, Metallurgy

07

D

C07D 213/62 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) C07D 213/69 (2006.01) C07D 213/74 (2006.01) C07D 213/80 (2006.01) C07D 239/28 (2006.01) C07D 239/34 (2006.01) C07D 239/48 (2006.01) C07D 239/50 (2006.01) C07D 239/52 (2006.01) C07D 401/02 (2006.01) C07D 401/12 (2006.01) C07D 403/02 (2006.01) C07D 405/02 (2006.01) C07D 409/02 (2006.01) C07D 413/02 (2006.01) C07D 417/02 (2006.01) C07D 471/04 (2006.01) C07D 473/34 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2192354

Corticotropin-releasing factor (CRF) antagonists having formulae (I), (II) or (III) wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 and R17 are as defined in the description, and processes for preparing them. These compounds and their pharmaceutically acceptable salts are useful in the treatment of CNS and stress-related disorders.

L'invention se rapporte à des antagonistes du facteur libérant la corticotrophine ayant les formules (I), (II) ou (III) dans lesquelles les lignes pointillées, A, B, Y, Z, G, R¿3?, R¿4?, R¿5?, R¿6?, R¿16? et R¿17? sont telles que définies dans la demande, et à leurs procédés de préparation. Ces composés et leurs sels pharmaceutiquement acceptables sont utilisés dans le traitement des troubles du système nerveux central (SNC) et des troubles relatifs au stress.

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