C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) C12N 9/00 (2006.01) C12N 9/12 (2006.01) C12N 15/31 (2006.01) C12N 15/77 (2006.01) C12P 1/04 (2006.01)
Patent
CA 2377378
Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated PTS proteins, mutated PTS proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of PTS genes in this organism.
L'invention concerne des molécules d'acide nucléique isolées, nommées molécules d'acide nucléique PTS qui codent pour de nouvelles protéines PTS de Corynebacterium glutamicum. L'invention concerne également des molécules d'acide nucléique antisens, des vecteurs d'expression recombinants contenant lesdites molécules d'acide nucléique PTS et des cellules hôtes dans lesquelles des vecteurs d'expression ont été introduits. L'invention concerne en outre des protéines PTS isolées, des protéines PTS mutées, des protéines de fusion, des peptides antigéniques et des méthodes servant à améliorer la production d'un composé voulu à partir de C. glutamicum sur la base d'une modification génétique des gènes PTS dans cet organisme.
Haberhauer Gregor
Kroger Burkhard
Pompejus Markus
Schroder Hartwig
Zelder Oskar
Basf Aktiengesellschaft
Borden Ladner Gervais Llp
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