Corynebacterium glutamicum genes encoding metabolic pathway...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/54 (2006.01) C07K 14/34 (2006.01) C12N 1/21 (2006.01) C12N 9/90 (2006.01) C12P 13/08 (2006.01) C12P 13/12 (2006.01)

Patent

CA 2402186

Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins form Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MP proteins, mutated MP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MP genes in this organism.

L'invention concerne des molécules d'acides nucléiques isolées nommées molécules d'acides nucléiques de voie métabolique, qui codent des nouvelles protéines de voie métabolique provenant de Corynebacterium glutamicum. Cette invention concerne également des molécules d'acides nucléiques antisens, des vecteurs d'expression recombinants renfermant des molécules d'acides nucléiques de voie métabolique et des cellules hôtes dans lesquelles lesdits vecteurs d'expression ont été introduits. Ladite invention a aussi trait à des protéines de voie métabolique isolées, des protéines de voie métabolique mutées, des protéines hybrides, des peptides antigéniques et des méthodes d'amélioration de la production d'un composé souhaité à partir de C. glutamicum en fonction du génie génétique des gènes de voie métabolique de cet organisme.

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