Corynebacterium glutamicum genes encoding proteins involved...

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/31 (2006.01) C07K 14/34 (2006.01) C12N 1/21 (2006.01) C12N 9/00 (2006.01) C12N 9/18 (2006.01) C12N 15/52 (2006.01) C12P 1/04 (2006.01) C12P 13/04 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2380863

Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCT proteins, mutated MCT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCT genes in this organism.

Cette invention concerne des molécules d'acides nucléiques isolées, dites molécules d'acides nucléiques SMP, qui codent pour de nouvelles protéines SMP tirées de (Corynebacterium glutamicum). L'invention concerne également des molécules d'acides nucléiques antisens, des vecteurs d'expression recombinante renfermant des molécules d'acides nucléiques SMP et des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits. De plus, l'invention concerne des protéines SMP isolées, des protéines SMP mutées, des protéines de fusion, des peptides antigéniques, ainsi que des procédés qui permettent d'améliorer la production d'un composé recherché à partir de C. glutamicum en fonction du génie génétique de gènes SMP dans cet organisme.

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