Corynebacterium glutamicum genes encoding proteins involved...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/31 (2006.01) C07K 14/34 (2006.01) C12N 9/00 (2006.01) C12N 9/18 (2006.01) C12N 15/52 (2006.01)

Patent

CA 2380871

Isolated nucleic acid molecules, designated HA nucleic acid molecules, which encode novel HA proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HA nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated HA proteins, mutated HA proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of HA genes in this organism.

L'invention concerne des molécules d'acide nucléique isolées, désignées molécules d'acide nucléique HA qui codent de nouvelles protéines HA à partir du Corynebacterium glutamicum. L'invention concerne également des molécules d'acide nucléique antisens, des vecteurs d'expression de recombinaison contenant des molécules d'acide nucléique HA, et des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits. L'invention traite, en outre, de protéines HA isolées, de protéines HA ayant subi une mutation, de protéines de fusion, de peptides antigènes et de procédés pour l'amélioration de la production d'un composé requis à partir du Corynebacterium glutamicum en fonction de la manipulation génétique de gènes HA dans cet organisme.

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