C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 5/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2305350
A polypeptide (8F4 molecule) with a T-cell costimulating biological activity is disclosed, as well as monoclonal antibodies against said 8F4 molecule and hybridoma cells which produce the monoclonal antibodies, the use as medicaments of substances which inhibit the biological activity of the disclosed 8F4 polypeptide, in particular monoclonal antibodies, natural or synthetic ligands, agonists or antagonists, in particular for preventing or treating diseases which involve the immune system, the use of said 8F4 molecule or cells containing said 8F4 molecule as medicaments, in particular for preventing or treating diseases which involve the immune system, and the use of substances which specifically recognise the disclosed polypeptide, in particular monoclonal antibodies, natural or synthetic ligands, agonists or antagonists, for diagnosing diseases which involve the immune system.
L'invention concerne un polypeptide (molécule 8F4) présentant une activité biologique de costimulation de lymphocytes T. L'invention concerne en outre des anticorps monoclonaux vis-à-vis de la molécule 8F4 et des cellules hybridomes qui produisent lesdits anticorps monoclonaux. L'invention concerne également l'utilisation de substances qui inhibent l'activité biologique dudit polypeptide 8F4, notamment des anticorps monoclonaux, des ligands naturels ou synthétiques, des agonistes et des antagonistes, utilisés comme médicaments pour prévenir ou traiter des maladies dans lesquelles intervient le système immunitaire. L'invention concerne par ailleurs l'utilisation de la molécule 8F4 ou de cellules contenant cette molécule, comme médicaments pour prévenir ou traiter des maladies dans lesquelles intervient le système immunitaire. L'invention concerne enfin l'utilisation de substances qui reconnaissent de façon spécifique le polypeptide de l'invention, en particulier des anticorps monoclonaux, des ligands naturels ou synthétiques, des agonistes et des antagonistes, utilisés comme médicaments pour le diagnostic de maladies dans lesquelles intervient le système immunitaire.
Bundesrepublik Deutschland Letztvertreten Durch Den Direktor Des
Goudreau Gage Dubuc
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