Costimulation of t-cell proliferation by a chimeric...

Details Costimulation of t-cell proliferation by a chimeric... Costimulation of t-cell proliferation by a chimeric...

A - Human Necessities

61

K

A61K 39/395 (2006.01)

Patent

CA 2283300

A soluble bispecific fusion protein consisting of: a) a binding domain which recognizes a specific surface molecule on a target cell, covalently linked to b) a domain capable of stimulating T-cell proliferation, can be used for a specific costimulation of a T-cell directed against said target cell.

L'invention concerne une protéine de fusion bispécifique soluble. Cette protéine se compose (a) d'un domaine de liaison qui reconnaît une molécule à surface spécifique sur une cellule cible, lié par covalence à (b) un domaine permettant de stimuler la prolifération des lymphocytes T. Cette protéine peut être utilisée pour une costimulation spécifique d'un lymphocyte T dirigé contre cette cellule cible.

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