Coumarin-based compounds

Details Coumarin-based compounds Coumarin-based compounds

C - Chemistry, Metallurgy

07

D

C07D 311/56 (2006.01) A61K 31/352 (2006.01) A61K 31/382 (2006.01) A61K 31/4709 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07D 215/20 (2006.01) C07D 335/06 (2006.01)

Patent

CA 2747811

Compounds including those of the Formula I where X, R1, R2 and subscript t are as defined herein, useful as .gamma.-secretase inhibitors, are provided, as are compositions comprising the compounds, as well as methods for use of the compounds for treating or preventing neurodegenerative diseases, such as, for instance, Alzheimer's disease, and cancer.

L'invention concerne des composés, notamment des composés de formule I dans laquelle X, R1, R2 et l'indice t sont définis ici, qui sont utiles comme inhibiteurs de ?-sécrétase, ainsi que des compositions comprenant les composés, ainsi que des procédés d'utilisation des composés pour traiter ou prévenir des maladies neurodégénératives, comme, par exemple, la maladie d'Alzheimer.

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