Coumarin compounds as microtubule stabilizing agents and...

A - Human Necessities – 61 – K

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A61K 31/37 (2006.01) A61K 31/00 (2006.01) A61K 31/337 (2006.01) A61K 31/35 (2006.01) A61K 31/352 (2006.01) A61K 31/366 (2006.01) A61K 31/475 (2006.01) A61K 31/565 (2006.01) A61K 45/06 (2006.01) C07D 311/10 (2006.01)

Patent

CA 2436735

Compounds and compositions for stabilizing microtubules are disclosed. Also disclosed are methods of inhibiting, preventing, regulating, modulating, attenuating, stabilizing, or affecting microtubule formation or function. Methods of treating, preventing or inhibiting diseases and disorders associated with microtubule formation, function, or both by administering a microtubule stabilizing agent such as coumarin is also disclosed.

L'invention concerne des composés et des compositions utilisés pour stabiliser les microtubules. L'invention concerne également des procédés permettant d'inhiber, de prévenir, de réguler, de moduler, d'atténuer, de stabiliser ou d'affecter la formation ou la fonction de microtubules. Sont également décrits des procédés de traitement, de prévention ou d'inhibition de maladies ou de troubles associés à la formation ou à la fonction de microtubules, ou aux deux, par administration d'un agent de stabilisation de microtubules tel que la coumarine.

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