Coumarin derivatives, process for their production and use...

C - Chemistry – Metallurgy – 07 – D

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C07D 311/18 (2006.01) A61K 31/352 (2006.01) A61K 31/37 (2006.01) A61K 31/41 (2006.01) A61K 31/4245 (2006.01) A61K 31/433 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61K 31/496 (2006.01) A61P 3/06 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 25/28 (2006.01) A61P 43/00 (2006.01) C07D 209/94 (2006.01) C07D 261/14 (2006.01) C07D 271/10 (2006.01) C07D 277/42 (2006.01) C07D 311/12 (2006.01) C07D 333/36 (2006.01) C07D 405/10 (2006.01) C07D 405/12 (2006.01) C07D 413/10 (2006.01) C07D 417/10 (

Patent

CA 2472419

Compounds represented by the general formula [I] or salts thereof, which are useful as lipid-rich plaque inhibitors and/or ACAT inhibitors: [I] wherein R1 and R2 are each hydrogen, halogeno, an optionally substituted linear hydrocarbon group, or hydroxyl which may be substituted with an optionally substituted linear hydrocarbon group, or R1 and R2 together with the carbon atoms adjacent thereto may form an optionally substituted carbocyle or a dihydrofuran ring which may have an oxo group; A is a benzene ring which may be further substituted; B is an aromatic ring which may be substituted; X is a free valency or a spacer whose main chain has 1 to 6 atoms; Y is carboxyl which may be esterified, carbamoyl which may be substituted, cyano, or an optionally substituted heterocyclic group bearing a hydrogen atom capable of causing deprotonation.

L'invention concerne des composés représentés par la formule générale [I] ou leurs sels, lesquels sont utiles en tant qu'inhibiteurs de plaque riches en lipide et/ou inhibiteurs d'ACAT, formule dans laquelle R?1¿ et R?2¿ représentent chacun hydrogène, halogéno et un groupe hydrocarbure linéaire facultativement substitué, ou hydroxyle pouvant être substitué par un groupe hydrocarbure linéaire facultativement substitué, ou R?1¿ et R?2¿ avec les atomes de carbone qui leur sont adjacents peuvent former un carbocycle facultativement substitué ou un cycle dihydrofurane pouvant avoir un groupe oxo ; A représente un cycle benzène pouvant également être substitué ; B représente un cycle aromatique pouvant être substitué ; X représente une valence libre ou un élément d'espacement dont la chaîne principale présente 1 à 6 atomes ; Y représente carboxyle pouvant être estérifié, carbamoyle pouvant être substitué, cyano, ou un groupe hétérocyclique facultativement substitué portant un atome d'hydrogène capable d'engendrer une déprotonation.

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