Coumarin derivatives to be used as anticoagulants

Details Coumarin derivatives to be used as anticoagulants Coumarin derivatives to be used as anticoagulants

C - Chemistry, Metallurgy

07

D

C07D 311/56 (2006.01) A61K 31/37 (2006.01)

Patent

CA 2445160

This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within the structure of the compounds are taught. The invention teaches methods of reducing the toxicity of drugs comprising the introduction of ester groups into drugs during the synthesis of the drug. This invention is also drawn to methods of treating coagulation disorders comprising the administration of compounds which have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester containing warfarin, analogs are also taught.

Cette invention concerne des composés plus facilement métabolisés par les systèmes de désintoxication métaboliques. Elle concerne en particulier des analogues de warfarine dont la structure est conçue pour comprendre des esters. Elle concerne aussi des méthodes de réduction de la toxicité des médicaments, qui consistent à introduire des groupes esters dans les médicaments lors de leur synthèse. L'invention concerne en outre des méthodes de traitement de troubles de la coagulation, qui consistent à administrer des composés mis au point pour être métabolisés par des hydrolases ou estérases sériques ou intracellulaires. Elle concerne enfin des compositions pharmaceutiques des analogues de warfarine contenant des esters.

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