C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 261/02 (2006.01) A61K 31/42 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2570780
One aspect of the present invention relates to isoxazoline derivatives that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising an isoxazoline derivative of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
Dans un mode de réalisation, la présente invention a trait à des dérivés d'isoxazoline de liaison aux protéines Bcl et d'inhibition de la fonction Bcl. Dans un autre mode de réalisation, la présente invention a trait à des compositions comportant un dérivé d'isoxazoline de l'invention. La présente invention a trait en outre à des procédés pour le traitement et la modulation de troubles associés à l'hyperprolifération, tels que le cancer.
Castro Alfredo C.
Deng Wei
Depew Kristopher M.
Foley Michael A.
Fritz Christian C.
Infinity Discovery Inc.
Infinity Pharmaceuticals Inc.
Smart & Biggar
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