Coumpounds for neutralising the effects of secreted pla2 iia

Details Coumpounds for neutralising the effects of secreted pla2 iia Coumpounds for neutralising the effects of secreted pla2 iia

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) C07K 16/40 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2539065

A compound comprising at least a structural entity which binds secretory phospholipase A2 IIA (sPLA2 IIA) or parts of it and more preferably human sPLA2 IIA and which a.) blocks at least one or more sPLA2 IIA function on cell surfaces or in a solution, preferably blood or other body fluids or from tissues, most preferably in vivo, b.) and/or depletes sPLA2 IIA from a solution, preferably blood or other body fluids or from tissues, most preferably in vivo.

Composé comprenant au moins une entité structurale se liant à la phospholipase sécrétoire A2 IIA (sPLA2 IIA), en totalité ou en partie et, de préférence, à sPLA2 IIA humaine. Ce composé: a) bloque au moins une ou plusieurs fonctions de sPLA2 IIA sur les surfaces cellulaires ou dans une solution, de préférence, du sang ou d'autres fluides corporels ou des tissus prélevés, de préférence in vivo; b) et/ou appauvrit sPLA2 IIA dans une solution, de préférence, du sang ou d'autres fluides corporels ou des tissus prélevés, de préférence, in vivo.

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