Coupling agents for radiolabeled antibody fragments

Details Coupling agents for radiolabeled antibody fragments Coupling agents for radiolabeled antibody fragments

C - Chemistry, Metallurgy

07

D

260/322.5

C07D 207/452 (2006.01) A61K 49/16 (2006.01) A61K 51/10 (2006.01)

Patent

CA 1257601

ABSTRACT Bifunctional coupling agents for joining radionuclide metal ions to biologically useful molecules, including antibody Fab' fragments are disclosed. The coupling agents are of the formula Image and contain a maleimide moiety and a paramagnetic or radionuclide chelating moiety. The maleimide can be used to selectively bind to free sulfhydryl, groups, or amine groups.

492611

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