Coupling method using selective amination of maleimide

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/765 (2006.01) C07D 207/404 (2006.01) C07D 207/416 (2006.01) C07D 451/06 (2006.01) C07D 451/12 (2006.01) C07D 489/02 (2006.01) C07H 15/252 (2006.01) C07K 1/10 (2006.01) C07K 1/13 (2006.01) C07K 17/00 (2006.01) G01N 33/532 (2006.01) G01N 33/543 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2156704

The instant invention is a method of coupling compounds comprising the septs of: a) forming maleimide derivative by reacting a maleimide containing compound having formula (I) with nn amine functional compound capable of displacing the N- hydroxysuccinimide group; and b) reacting the derived maleimide of step (n) with a sccond amine functional compound.

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