C - Chemistry – Metallurgy – 08 – H
Patent
C - Chemistry, Metallurgy
08
H
195/35, 530/15.0
C08H 1/00 (2006.01) A61K 39/00 (2006.01) G01N 33/48 (2006.01) G01N 33/531 (2006.01)
Patent
CA 1127985
ABSTRACT OF THE DISCLOSURE The products of the invention are obtained by a method which consists of: oxidizing cytidine-diphosphocholine, fixing the dialdehyde obtained by the preceding oxidation of the ribose of the cytidine on NH2 groups of amino compound in alkaline aqueous solution, stabilizing the coupling thus formed by reduction and recovering the macromolecular product thus obtained in the form of an aqueous solution. The latter can be freeze-dried to provide a powder suitable for preservation. The coupling occurs between the oxidized ribose groups of the cytidine-diphosphocholine and the lysine residues of the amino compounds. The products of the invention are suitable as vaccines against parasites belonging to the class of those containing molecules bound to a phosphoryl- choline residue, such as intestinal or respiratory parasites. The product may be used for measuring biological compounds reacting with phosphorylcholine, such as by fixing on sheep's red blood cells, if necessary, treated with glutaraldehyde.
310742
Luffau Gerard
Pery Pierre
Petit Agnes
Poulain Joelle
Gowling Lafleur Henderson Llp
Institut National de La Recherche Agronomique (inra)
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