Coupling unit of (6-4) photoproduct, process for preparing...

C - Chemistry – Metallurgy – 07 – H

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C07H 21/00 (2006.01)

Patent

CA 2195364

-35- Disclosed are a coupling unit of a (6-4) photoproduct represented by the formula (I): Image (I) wherein R1 represents a protective group, R2 represents a methyl group or a 2-cyanoethyl group, and R3 represents Image or Image wherein R5 represents a methyl group or a 2-cyanoethyl group, and R6 represents a -N(R')(R") group, a N-morpholino group, a N-pyrrolidinyl group or a 2,2,6,6-tetramethyl-N-piperidyl group where R' and R" each represent a lower alkyl group, a process for preparing the same, a process for preparing an oligonucleotide containing a (6-4) photoproduct by using the same, and a process for preparing DNA containing a (6-4) photoproduct by using the same.

Unité de couplage d'un photoproduit (6-4) de formule (I) : Image (I) où R1 représente un groupe protecteur, R2 un groupe méthyle ou 2-cyanoéthyle, R3 représente Image ou Image où R5 est un groupe méthyle ou 2-cyanoéthyle, R6 représente un groupe -N(R')(R"), N-morpholino, N-pyrrolidinyle ou 2,2,6,6-tétraméthyl-N-pipéridyle, avec R' et R" représentant chacun un alkyle inférieur; méthode de préparation du composé et méthode de préparation d'un oligonucléotide renfermant un photoproduit (6-4) en utilisant le même composé; méthode pour préparer de l'ADN renfermant un photoproduit (6-4) en utilisant le même composé.

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