Covalent attachment of anticoagulant and the like onto...

A - Human Necessities – 61 – L

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167/323

A61L 27/00 (2006.01) A61L 33/00 (2006.01)

Patent

CA 1302896

COVALENT ATTACHMENT OF ANTICOAGULANTS AND THE LIKE ONTO BIOMATERIALS Abstract of the Disclosure A substrate for medical devices and a process for making the substrate is provided, the substrate having on at least part of its surface a blood-compatible surface produced by coupling a physiologically active substance to the surface. The physiologically active substance is one having an inhibitory effect on the formation of blood clots and/or is capable of breaking down blood clots formed. The physiologically active substance is bonded to a polyacid, and the polyacid is attached to the surface by a covalent bond.

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