A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 38/16 (2006.01) A61P 31/00 (2006.01) A61P 31/04 (2006.01) A61P 35/00 (2006.01) A61K 31/357 (2006.01) A61K 38/40 (2006.01) A61K 38/42 (2006.01)
Patent
CA 2488360
In one aspect, the invention provides covalent conjugates between artemisinin~ related endoperoxides and iron-carrying proteins. In some embodiments, the covalent conjugates comprise artelinate and holotransferrin. In another aspect, the invention provides methods for administering the covalent conjugates of the invention to treat cancer and infections by pathogens that bind iron-carrying proteins.
Dans un mode de réalisation, l'invention concerne des conjugués covalents entre des endopéroxydes liés à l'artémisinine et des protéines porteuses de fer. Dans quelques modes de réalisation, les conjugués covalents comprennent de l'artélinate et de l'holotransferrine. Dans un autre mode de réalisation, l'invention concerne des procédés d'administration des conjugués covalents selon l'invention, aux fins de traitement du cancer et d'infections induites par des pathogènes se liant aux protéines porteuses de fer.
Lai Henry C.
Sasaki Tomikazu
Singh Narendra P.
Mbm Intellectual Property Law Llp
University Of Washington
LandOfFree
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