Covalent conjugates of lipid and oligonucleotide

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 21/00 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07J 51/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/546 (2006.01)

Patent

CA 2049028

2049028 9010448 PCTABS00002 A conjugate is provided wherein a lipid is covalently coupled to an oligonucleotide having a nucleotide sequence that is either of interest or substantially complementary to a nucleotide sequence of interest. The conjugate is useful for nucleic acid purification, diagnostic methods, and therapeutic applications. The therapeutic aspect includes conjugates wherein the oligonucleotide contains an antisense nucleotide sequence to a sequence encoding a polypeptide responsible for a pathogenic disorder.

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