Covalent immobilized antibodies on polymeric beads

Details Covalent immobilized antibodies on polymeric beads Covalent immobilized antibodies on polymeric beads

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) G01N 15/10 (2006.01) G01N 21/64 (2006.01) G01N 33/543 (2006.01) G01N 33/554 (2006.01) G01N 33/564 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2184282

The invention relates to polymeric colloidal particles having a short, low molecular weight diamine spacer or polymeric, crosslinked aminodextran coating that is functionalized to bind a pendent protein such as antibody, to methods of making such particles, to the use of such particles in biological assays, to the effects of thermal and freeze-drying treatment of such particles on their stability and structure as detected from their interactions with leukocytes in biological assays with whole blood on the nonspecific interactions between leukocytes and aminodextran-coated beads.

L'invention concerne des particules polymères colloïdales comprenant un espaceur diamine court de faible poids molaire ou un revêtement d'aminodextrane polymère réticulé qui est rendu fonctionnel pour fixer une protéine pendante telle qu'un anticorps. L'invention porte également sur des procédés de fabrication de ces particules, sur leur utilisation dans des essais biologiques, sur les effets du traitement thermique et de lyophilisation de ces dernières sur leur stabilité et leur structure, effets qui sont déterminés en fonction de leurs interactions avec les leucocytes dans des dosages biologiques réalisés avec du sang entier, relatifs aux interactions non spécifiques entre les leucocytes et les perles enrobées d'aminodextrane.

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