Covalently-linked complexes and methods for enhanced...

Details Covalently-linked complexes and methods for enhanced... Covalently-linked complexes and methods for enhanced...

C - Chemistry, Metallurgy

12

N

195/35, 530/17.0

C12N 11/02 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C07K 14/415 (2006.01) C07K 17/02 (2006.01) C12N 15/62 (2006.01)

Patent

CA 1334513

Covalently-linked complexes (CLCs) for targeting a defined population of cells, comprising a targeting protein; a cytotoxic agent; and an enhancing moiety, wherein the enhancing moiety is capable of promoting CLC- target cell interaction are disclosed. Methods for using the claimed CLCs to obtain enhanced in vivo cytotoxicity and enhanced in vivo imaging are also described.

608198

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