C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) C07H 19/23 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2223678
Minor groove binding molecules are covalently bound to oligonucleotides which in their base sequence are complementary to a target sequence of single stranded or double stranded DNA, RNA or hybrids thereof. The covalently bound oligonucleotide minor groove binder conjugates strongly bind to the target sequence of the complementary strand.
Des molécules se liant dans le petit sillon sont liées de façon covalente à des oligonucléotides qui sont complémentaires, de par leur séquence de base, avec une séquence cible d'ADN ou d'ARN à simple ou double brin ou avec leurs hybrides. Ces produits de conjugaison oligonucléotides-liants dans le petit sillon, liés de façon covalente, se lient fermement à la séquence cible du brin complémentaire.
Gamper Howard B.
Kutyavin Igor V.
Lukhtanov Eugeny A.
Meyer Rich B. Jr.
Epoch Biosciences Inc.
Epoch Pharmaceuticals Inc.
Gowling Lafleur Henderson Llp
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