Covalently-modified bacterial polysaccharides, stable...

Details Covalently-modified bacterial polysaccharides, stable... Covalently-modified bacterial polysaccharides, stable...

C - Chemistry, Metallurgy

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C07K 9/00 (2006.01) A61K 39/02 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) A61K 47/48 (2006.01) C07K 17/06 (2006.01) C07K 17/10 (2006.01) G01N 33/531 (2006.01)

Patent

CA 1259450

TITLE OF THE INVENTION COVALENTLY-MODIFIED BACTERIAL POLY- SACCHARIDES, STABLE COVALENT CONJUGATES OF SUCH POLYSACCHARIDES AND IMMUNOGENIC PROTEINS WITH BIGENERIC SPACERS, AND METHODS OF PREPARING SUCH POLYSACCHARIDES AND CONJUGATES AND OF CONFIRMING COVALENCY ABSTRACT OF THE DISCLOSURE Covalently modified bacterial polysaccharides and proteins; covalent conjugates of such polysaccharides linked by a bigeneric spacer, which permits proof of covalency and facilitates purification of conjugated materials, with immunogenic bacterial membrane or other proteins, which conjugates are useful components of bacterial vaccines; and methods of preparing such polysaccharides, proteins and conjugates and of confirming the covalency of the linkage between polysaccharides and proteins.

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