Covalently-modified neutral bacterial poly- saccharides,...

Details Covalently-modified neutral bacterial poly- saccharides,... Covalently-modified neutral bacterial poly- saccharides,...

C - Chemistry, Metallurgy

07

K

167/103, 530/17.

C07K 17/10 (2006.01) A61K 39/116 (2006.01) A61K 47/48 (2006.01) C08B 37/00 (2006.01)

Patent

CA 1256250

2593P/0880A 17178 TITLE OF THE INVENTION COVALENTLY-MODIFIED NEUTRAL BACTERIAL POLY- SACCHARIDES, STABLE COVALENT CONJUGATES OF SUCH POLYSACCHARIDES AND IMMUNOGENIC PROTEINS, AND METHODS OF PREPARING SUCH POLYSACCHARIDES AND CONJUGATES ABSTRACT OF THE DISCLOSURE Covalently-modified neutral bacterial polysaccharides; covalent conjugates of such polysaccharides linked by a bigeneric spacer, with immunogenic bacterial membrane or other proteins, which conjugates are useful components of bacterial vaccines; and methods of preparing such polysaccharides and conjugates.

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