Cover slip holder for bilateral and unilateral simulation of...

B - Operations – Transporting – 01 – F

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B01F 5/02 (2006.01) B01F 5/04 (2006.01) C12M 1/34 (2006.01) C12M 1/40 (2006.01) G01N 11/04 (2006.01) G01N 33/49 (2006.01) G01N 33/86 (2006.01) G09B 23/28 (2006.01)

Patent

CA 2112681

2112681 9300989 PCTABS00019 The invention relates to a perfusion chamber (1), a mixing device (21), and a cover slip holder (6) for use together with the perfusion chamber. The bottom of the cover slip holder is provided with cross-located grooves for installing cover slips of plastic or any other material, and in which the cover slips are elevated in comparison to each other in such a way that the cross-sectional area of the flow channel is constricted unilaterally, for simulation of thrombogenesis in human blood vessels with stenosis. The bottom of the perfusion chamber, in the measure chamber, can also have an elevation into the flow channel in the measure chamber which together with the elevated cover slip holder bottom produces a bilateral constriction of the cross-sectional area of the measure chamber. The mixing device (21) is connected to the system upstream of the perfusion chamber (1) and produces homogenous mixing of solutions added to the blood flow. The use of the perfusion chamber (1), the cover slip holder (6), and the mixing device (21) is described.

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