Covered stent with controlled therapeutic agent diffusion

Details Covered stent with controlled therapeutic agent diffusion Covered stent with controlled therapeutic agent diffusion

A - Human Necessities

61

F

A61F 2/06 (2006.01) A61K 9/22 (2006.01) A61K 9/52 (2006.01) A61K 31/74 (2006.01)

Patent

CA 2584714

A covered stent (18) includes a generally tubular stent body (16) having inner and outer stent body surfaces (26, 24). A sleeve of porous material (20) encloses the stent body and has inner and outer portions (40, 42) opposed to the inner and outer stent body surfaces. A therapeutic agent is located along the stent body, the agent being diffusible through the material. A diffusion barrier (30) is located between the inner material portion and the agent along the stent. The diffusion barrier prevents passage of at least a significant amount the agent through the inner portion of the sleeve of porous material. A diffusion restrictor (32) is located between the outer portion of the sleeve of porous material and the agent along the stent. The diffusion restrictor permits passage of the agent through the inner material portion at a therapeutic level.

L'invention concerne une endoprothèse couverte (18) comprenant un corps d'endoprothèse généralement tubulaire (16) possédant des surfaces intérieure et extérieure (26, 24). Une gaine de matière poreuse (20) entoure le corps d'endoprothèse et comporte des parties intérieure et extérieure (40, 42) opposées auxdites surfaces intérieure et extérieure. Un agent thérapeutique est situé le long du corps d'endoprothèse, cet agent pouvant se diffuser à travers la matière. Une barrière de diffusion (30) est située entre la partie de matière intérieure et l'agent le long de l'endoprothèse. La barrière de diffusion empêche le passage d'au moins une quantité importante de l'agent à travers la partie intérieure de la gaine de matière poreuse. Un limiteur de diffusion (32) est situé entre la partie extérieure de la gaine de matière poreuse et l'agent le long de l'endoprothèse. Le limiteur de diffusion permet le passage de l'agent à travers la partie de matière intérieure en quantité thérapeutique.

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