Cox-2 inhibitors in combination with nmda-blockers for...

Details Cox-2 inhibitors in combination with nmda-blockers for... Cox-2 inhibitors in combination with nmda-blockers for...

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61K 31/13 (2006.01) A61K 31/485 (2006.01)

Patent

CA 2351224

A method of alleviating a pain state not associated with a cough condition is provided which comprises administering to a mammal exhibiting a pain state not associated with a cough condition a cyclooxygenase-2 inhibitor with a nontoxic NMDA receptor antagonist and/or a nontoxic substance that blocks at least one major intracellular consequence of NMDA receptor activation.

L'invention se rapporte à une méthode visant à soulager un état douloreux qui n'est pas accompagné de toux, et consistant à administrer à un mammifère présentant un état de douleur non accompagné de toux un inhibiteur de cyclooxygénase-2 ainsi qu'un antagoniste non toxique des récepteurs de NMDA et/ou une substance non toxique qui supprime au moins une des conséquences intracellulaires majeures de l'activation des récepteurs de NMDA.

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