Cox-2-targeted imaging agents

Details Cox-2-targeted imaging agents Cox-2-targeted imaging agents

A - Human Necessities

61

K

A61K 49/00 (2006.01)

Patent

CA 2530408

The presently disclosed subject matter provides a method for synthesizing a radiological imaging agent by reacting a COX-2-selective ligand with a compound comprising a detectable group, wherein the COX-2- selective ligand is a derivative of a non-steroidal anti-inflammatory drug (NSAID) comprising an ester moiety or a secondary amide moiety. Also provided are compositions that are synthesized using the method, as well as methods of using the compositions of the presently disclosed subject matter.

L'invention porte sur le procédé de synthèse un agent d'imagerie radiologique consistant à faire réagir un ligand COX-2 sélectif avec un composé comprenant un groupe détectable. Un tel ligand est un dérivé de médicament anti-inflammatoire non stéroïdien (NSAID) comportant un fragment d'ester et un fragment d'amide secondaire. L'invention porte également sur des composition obtenues à l'aide dudit procédé, et sur leurs utilisations.

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