Coxsackie virus-derived vector system for gene transfer

Details Coxsackie virus-derived vector system for gene transfer Coxsackie virus-derived vector system for gene transfer

C - Chemistry, Metallurgy

12

N

C12N 15/41 (2006.01) A61K 48/00 (2006.01) C07K 14/085 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2382090

The invention relates to a recombinant RNA molecule that can at least partially be translated in a target cell and that contains a non-infectious Coxsackie virus group B virus genome, preferably of the B3 serotype, and at least one foreign gene that induces a desired function in the target cell, for example within the context of a genetic therapy. The RNA molecule can be encoded by a vector plasmid and/or can be packaged as a genome into a virion by which the target cell can then be infected. The invention further relates to methods for producing the RNA molecule, the virions and the vector plasmid, and to corresponding kits.

L'invention concerne une molécule d'ARN recombiné pouvant être traduite au moins en partie dans une cellule cible. Cette molécule d'ARN présente un génome viral non infectieux du virus Coxsackie du groupe B, de préférence du sérotype B3, et au moins un gène étranger qui provoque une fonction souhaitée, par exemple dans le cadre d'une thérapie génique, dans la cellule cible. Cette molécule d'ARN peut être codée par un plasmide vecteur et/ou être empaquetée sous forme de génome dans un virion permettant d'infecter la cellule cible. L'invention concerne en outre des procédés pour produire la molécule d'ARN, les virions et le plasmide vecteur, ainsi que des kits correspondants.

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