C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12P 19/34 (2006.01)
Patent
CA 2556611
The invention can be summarized as follows. There is provided a method for amplifying hypomethylated genomic nucleotide sequences and/or hypermethylated genomic nucleotide sequences and comparing the methylation state between different samples, for example control and test samples. Also disclosed is a microarray based method for analysing hypo and/or hypermethylated genomic nucleotide sequence. Further, kits comprising reagents for practising the method are provided.
L'invention concerne une méthode d'amplification de séquences nucléotidiques génomiques hypométhylées et/ou de séquences nucléotidiques génomiques hyperméthylées et de comparaison de l'état de méthylation entre des échantillons différents, par exemple des échantillons témoins et d'essai. L'invention concerne également une méthode basée sur un microréseau permettant d'analyser une séquence nucléotidique génomique hypo et/ou hyperméthylée. L'invention concerne en outre des trousses comprenant des réactifs permettant de mettre en oeuvre ladite méthode.
Petronis Arturas
Schumacher Axel
Centre For Addiction And Mental Health
Gowling Lafleur Henderson Llp
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