Cpg-packaged liposomes

Details Cpg-packaged liposomes Cpg-packaged liposomes

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 9/127 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2544240

Liposomes are known to enhance the activity of K- (B-) type CpGs which trigger the production of IL-12. In the present invention, the surprising finding was made that liposomes also enhance the activity of D- (A-) type CpGs, leading to the production of IFN.alpha. in vivo. These findings are relevant for the humans situation, since IFN.alpha. rather than IL-12 is the key cytokine for the induction of Th I responses and anti-viral protection in humans.

Les liposomes sont connus pour accroître l'activité des CpG de type K- (B-) déclenchant la production de IL-12. Les liposomes selon l'invention augmentent également l'activité des CpG de type D- (A-), entraînant la production de IFNa in vivo. Ces liposomes présentent un intérêt particulier pour l'être humain, du fait que IFNa, plutôt que IL-12, est la cytokine clé pour l'induction des réponses de Th1 et la protection antivirale chez l'être humain.

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