C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2389765
The present invention is directed to nucleic acid molecules and polypeptides encoding a CpG receptor (CpG-R). The CpG-R contains a THD, interacts with the MyD88 adapter protein, and may bind to CpG oligonucleotides. The present invention is also directed to antibodies against CpG-R and to methods of modulating an immune response and to methods of identifying compounds which bind to and/or modulate CpG-R.
L'invention concerne des molécules d'acides nucléiques et des polypeptides codant un récepteur de CpG (CpG-R). Le CpG-R renferme un domaine d'homologie Toll (THD), interagit avec la protéine d'adaptation MyD88, et peut se lier avec des oligonucléotides CpG. L'invention concerne également des anticorps vis-à-vis du CpG-R, des procédés de modulation de réponse immunitaire et des procédés relatifs à l'identification de composés qui se lient avec le CpG-R et/ou modulent le CpG-R.
Borden Ladner Gervais Llp
Chiron Corporation
Novartis Vaccines And Diagnostics Inc.
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