Creatine analogs having antiviral activity

Details Creatine analogs having antiviral activity Creatine analogs having antiviral activity

C - Chemistry, Metallurgy

07

D

C07D 233/46 (2006.01) A61K 31/18 (2006.01) A61K 31/195 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/505 (2006.01) A61K 31/66 (2006.01) A61K 31/675 (2006.01) C07C 257/14 (2006.01) C07C 311/51 (2006.01) C07D 207/22 (2006.01) C07D 233/06 (2006.01) C07D 233/48 (2006.01) C07D 233/88 (2006.01) C07D 487/04 (2006.01) C07F 9/22 (2006.01) C07F 9/6506 (2006.01)

Patent

CA 2125563

2125563 9312781 PCTABS00024 The present invention relates to the use of creatine and suitable creatine analogs, such as cyclocreatine, as antiviral agents. These compounds can be used as antiviral agents against a variety of viruses, particularly DNA viruses, such as Herpes viruses (e.g., HSV-1, HSV-2, cytomegaloviruses, Varicella-Zoster virus) and adenovirus. The invention further relates to suitable creatine analogs having antiviral activity, including creatine analogs that can be phosphorylated by creatine kinase and the phosphorylated forms of the creatine analogs.

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