Creation of tissue engineered female reproductive organs

Details Creation of tissue engineered female reproductive organs Creation of tissue engineered female reproductive organs

A - Human Necessities

61

L

A61L 27/38 (2006.01) A61L 27/18 (2006.01) C12N 5/00 (2006.01) C12N 11/00 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2467558

The invention is directed to compositions and methods for reconstructing artificial female reproductive organs. The constructs and methods of the invention can be used for ameliorating congenital malformations and disorders of female reproductive tract using tissue engineered female reproductive organs, such as the uterus, vagina, cervix, and fallopian tubes. These tissues engineered female reproductive organs can be generated by perfusing cultured cell populations derived from cells of the female reproductive tissues, such as uterine, vaginal, cervical, fallopian tube epithelial cells as well as smooth muscle cells.

L'invention concerne des compositions et des méthodes de reconstruction d'organes reproducteurs féminins artificiels. Les constructions et les méthodes de l'invention s'utilisent pour améliorer des malformations congénitales et des troubles des voies reproductrices féminines au moyen d'organes reproducteurs féminins, tels que l'utérus, le vagin, le col de l'utérus, et les trompes de Fallope, construits à partir de tissus. Lesdits organes reproducteurs féminins construits à partir de tissus peuvent être générés par perfusion de populations de cellules cultivées dérivées de cellules de tissus reproducteurs féminins, telles que des cellules épithéliales de l'utérus, du vagin, du col de l'utérus ou des trompes de Fallope, ainsi que des cellules de muscles lisses.

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