Crf receptor antagonists and methods relating thereto

Details Crf receptor antagonists and methods relating thereto Crf receptor antagonists and methods relating thereto

C - Chemistry, Metallurgy

07

D

C07D 471/16 (2006.01) A61K 31/4985 (2006.01) A61P 25/00 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 231/00 (2006.01) C07D 239/00 (2006.01) C07D 241/00 (2006.01) C07D 487/16 (2006.01)

Patent

CA 2350642

CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. The CRF receptor antagonists of this invention have structure (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein <i>n</i>, <i>m</i>, A, B, C, R, R1, R2 and Ar are as defined herein. Compositions containing a CRF receptor antagonist in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same.

L'invention concerne des antagonistes de récepteurs du CRF, qui sont utiles dans le traitement de diverses affections, notamment dans le traitement d'affections dans lesquelles on observe une hypersécrétion de CRF chez les animaux à sang chaud, en particulier les accidents vasculaires cérébraux. Les antagonistes de récepteurs du CRF de l'invention présentent la structure de la formule (I), dans laquelle <i>n</i>, <i>m</i>, A, B, C, R, R¿1?, R¿2?, et Ar sont tels que définis dans le descriptif, y compris leurs stéréoisomères et leurs sels acceptables sur le plan pharmaceutique. L'invention concerne également des compositions contenant un antagoniste de récepteur du CRF en combinaison avec un excipient acceptable sur le plan pharmaceutique, ainsi que des méthodes d'utilisation de ces compositions.

Affiliated with

Also associated with

Rating

Crf receptor antagonists and methods relating thereto does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Crf receptor antagonists and methods relating thereto, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crf receptor antagonists and methods relating thereto will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1657813