Crf receptor antagonists and methods relating thereto

Details Crf receptor antagonists and methods relating thereto Crf receptor antagonists and methods relating thereto

C - Chemistry, Metallurgy

07

D

C07D 487/16 (2006.01) A61K 31/4985 (2006.01) A61K 31/551 (2006.01) A61P 25/00 (2006.01) C07D 221/00 (2006.01) C07D 235/00 (2006.01) C07D 239/00 (2006.01) C07D 241/00 (2006.01) C07D 243/00 (2006.01) C07D 471/16 (2006.01)

Patent

CA 2349904

Compounds are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in warmblooded animals, including stroke. The compounds of this invention have structures (I): (a) wherein n, m, R, R1, R2, X and Ar are as defined herein, including stereoisomes and pharmaceutically acceptable salts thereof.

L'invention concerne des composés qui sont utiles dans le traitement de diverses affections, notamment dans le traitement d'affections dans lesquelles on observe une hypersécrétion de CRF chez les animaux à sang chaud, en particulier les accidents vasculaires cérébraux. Les composés de l'invention présentent la structure de la formule (I), dans laquelle n, m, R, R¿1?, R¿2?, X et Ar sont tels que définis dans le descriptif, y compris leurs stéréoisomères et leurs sels acceptables sur le plan pharmaceutique.

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