Crhr2 peptide agonists and uses thereof

Details Crhr2 peptide agonists and uses thereof Crhr2 peptide agonists and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/575 (2006.01) A61K 38/22 (2006.01) C07K 16/18 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2742710

The present invention relates to novel peptides that are selective corticotropin releasing hormone receptor type 2 (CRHR2) agonists and compositions thereof for the treatment, amelioration or inhibition of cardiovascular conditions, including but not limited to heart failure. The novel peptide agonist preferably comprise modifications that include pegylated peptides. Furthermore, the present invention also relates to methods for the treatment and prevention of a disease or disorder related to CRHR2 activity.

La présente invention concerne de nouveaux peptides qui sont des agonistes sélectifs du récepteur d'hormone de libération de la corticotropine de type 2 (CRHR2) et des compositions de ces peptides destinées au traitement, à l'amélioration ou à l'inhibition d'états cardio-vasculaires, comprenant en autre l'insuffisance cardiaque. Le nouvel agoniste peptidique comporte de préférence des modifications qui incluent des peptides pégylés. En outre, la présente invention concerne également des procédés destinés au traitement et à la prévention d'une maladie ou d'un trouble associé à l'activité de CRHR2.

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