Cripto-specific antibodies

Details Cripto-specific antibodies Cripto-specific antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 39/395 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2480119

The invention provides Cripto-specific antibodies, or biologically functional fragments thereof, and uses thereof. Antibodies which bind Cripto and inhibit Cripto activity are provided. Antibodies which bind Cripto and inhibit the interaction between Cripto and ALK4 and/or between Cripto and Activin B are provided. Antibodies which bind Cripto and inhibit tumor growth are also provided. Antibodies which bind Cripto, inhibit Cripto activity, and inhibit tumor growth are also provided. The invention also provides methods of using these antibodies in therapeutic, diagnostic, and research application.

L'invention concerne des anticorps spécifiques au cripto ou des fragments biologiquement fonctionnels de ces derniers, et leurs utilisations. L'invention concerne également des anticorps qui lient le cripto et inhibent l'activité du cripto ; des anticorps qui lient le cripto et inhibent l'interaction entre le cripto et ALK4 et/ou entre le cripto et l'activine B ; des anticorps qui lient le cripto et inhibent la croissance tumorale ; des anticorps qui lient le cripto, inhibent l'activité du cripto et inhibent la croissance tumorale. L'invention concerne des procédés utilisant ces anticorps dans les applications thérapeutiques, diagnostiques et de recherche.

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