Cripto tumour polypeptide

Details Cripto tumour polypeptide Cripto tumour polypeptide

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C12N 5/0783 (2010.01) A61K 38/18 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C12N 15/18 (2006.01)

Patent

CA 2420087

Compositions and methods for the therapy and diagnosis of cancer, particularly lung, colon, colorectal and breast cancer, are disclosed. Illustrative compositions comprise one or more Cripto tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung, colon, colorectal and breast cancer.

L'invention concerne des compositions et des procédés destinés au traitement et au diagnostic du cancer, notamment le cancer du poumon, le cancer du côlon, le cancer colorectal et le cancer du sein. Les compositions illustrées comprennent un ou plusieurs polypeptides de tumeur Crypto des parties immunogènes de ceux-ci, des polynucléotides codant ces polypeptides, un antigène présentant une cellule exprimant ces polypeptides et des cellules T qui sont spécifiques aux cellules exprimant de tels polypeptides. Les compositions de l'invention sont, par exemple, utiles dans le diagnostic, la prévention et/ou le traitement des maladies, notamment le cancer du poumon, le cancer du côlon, le cancer colorectal et le cancer du sein.

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