Cromolyn derivatives and related methods of imaging and...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 311/66 (2006.01) A61K 31/352 (2006.01) A61K 49/00 (2006.01) A61P 25/28 (2006.01) C07B 59/00 (2006.01)

Patent

CA 2751125

Novel cromolyn analogs useful as imaging agents for detecting atherosclerotic plaques and for treating atherosclerosis and Alzheimer's Disease, and methods of making the cromolyn analogs, are disclosed. The cromolyn analogs have the general formula (I), or formula (II); wherein X is OH, C1-C6 alkoxyl, 18F, or 19F; Y and Z are independently selected from a C1-C6 alkyl, C1C6 alkoxyl, halogen, un-substituted or C1-C6 substituted amine, 18F, 19F, or H; and n is 1, 2, or 3; and wherein for structure (I), if n are both 1 and Y and Z are both H, X is not OH.

L'invention concerne de nouveaux analogues d'acide cromoglycique utiles comme agents d'imagerie pour détecter des plaques athérosclérotiques et traiter l'athérosclérose et la maladie d'Alzheimer, et des procédés de fabrication de ces analogues d'acide cromoglycique. Les analogues d'acide cromoglycique sont représentés par la formule générale (I) ou (II), dans lesquelles X représente OH, un alcoxyle en C1-C6, 18F ou 19F; Y et Z sont sélectionnés indépendamment dans le groupe comprenant un alkyle en C1-C6, un alcoxyle CpC6, un halogène, une amine non substituée ou substituée en C1-C6, 18F, 19F ou H; et n représente 1, 2 ou 3; et concernant la structure (I), si n représente 1 et Y et Z représentent les deux H, X ne représente pas OH.

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