Cross-linked antibodies and processes for their preparation

Details Cross-linked antibodies and processes for their preparation Cross-linked antibodies and processes for their preparation

G - Physics

01

N

167/129, 167/139

G01N 33/60 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01)

Patent

CA 2026312

2026312 9009195 PCTABS00001 Cross-linked antibody conjugates are described which have at least one interchain bridge containing a reporter or effector molecule. The bridge may be the residue of a homo- or heterofunctional cross-linking reagent, and is located away from the antigen binding domains of the antibody. The antibody conjugates have an enhanced binding capacity and in vivo have good blood clearance and, in the presence of a tumour high tumour: blood and tumour: bone ratios. The conjugates are of use in the diagnosis and therapy of e.g. tumours and may be prepared by reaction of a cross-linking reagent with an antibody.

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