Cross-linked hyaluronic acids and medical uses thereof

Details Cross-linked hyaluronic acids and medical uses thereof Cross-linked hyaluronic acids and medical uses thereof

C - Chemistry, Metallurgy

08

B

C08B 37/08 (2006.01) A61L 27/20 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2350667

New cross-linked hyaluronic acids obtainable by reaction of activated carboxylic groups of native linear hyaluronic acid, of extractive or biosynthetic source, with a polyamine, particularly a linear alkyl diamine. The cross-linked hyaluronic acids of the invention can optionally be sulphated or hemisuccinylated and are useful as substitutes of synovial fluid, vitreous humor, as controlled-release matrices forms medicaments, as healing and antiadhesive agents, and for the preparation of vascular prosthesis, biohybrid organs, healing devices, ophthalmic and otological compositions, prosthesis, implants and medical devices.

On peut obtenir de nouveaux acides hyaluroniques réticulés en faisant réagir les groupes carboxyliques activés d'un acide hyaluronique linéaire natif, obtenu par extraction ou par biosynthèse, avec une polyamine, notamment une alkyl-diamine linéaire. Les acides hyaluroniques réticulés de l'invention, qui peuvent éventuellement être sulfatés ou hémisuccinylés, sont utiles comme substituts du liquide synovial ou de l'humeur vitrée, comme matrices de médicaments à libération contrôlée ou agents cicatrisants et anti-adhésifs, et pour la préparation de prothèses vasculaires, d'organes biohybrides, de dispositifs de cicatrisation, de compositions ophtalmiques et auriculaires, de prothèses, d'implants et de dispositifs chirurgicaux.

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